Question

ANSWER ALL QUESTIONS FULLY AND CORRECTLY

5-1 T cells recognize antigen when the antigen a. forms a complex with membrane-bound MHC molecules on another host-derived cell b. is internalized by T cells via phagocytosis and subsequently binds to T-cell receptors in the endoplasmic reticulum c. is presented on the surface of a B cell on membrane-bound immunoglobulins d. forms a complex with membrane-bound MHC molecules on the T cell e. bears epitopes derived from proteins, carbohydrates, and lipids. 5-2 a. b. c. d. e. T-cell receptors structurally resemble the Fc portion of immunoglobulins MHC class I molecules secreted antibodies a single Fab of immunoglobulins (but membrane bound) CD3 & chains. 5-3 If viewing the three-dimensional structure of a T-cell receptor from the side, with the T-cell membrane at the bottom and the receptor pointing upwards, which of the following is inconsistent with experimental data? a. The highly variable CDR loops are located across the top surface. b. The membrane-proximal domains consist of C, and C. c. The portion that makes physical contact with the ligand comprises V, and C, the domains farthest from the T-cell membrane. d. The transmembrane regions span the plasma membrane of the T cell. e. The cytoplasmic tails of the T-cell receptor a and B chains are very short. 5 4 Unlike B cells, T cells do not engage in any of the following processes except a. alternative splicing to produce a secreted form of the T-cell receptor b. alternative splicing to produce different isoforms of the T- cell receptor c. isotype switching d. somatic hypermutation e. somatic recombination

Answer 1

5-1- (a)

5-2-(d)

5-3-(c)

5-4-(e)

5-5-(b)

5-6-(f)

5-7-(a)

5-8-(c)

5-9-(b)

5-10-(e)

5-11- proteosome and ERAP