Briefly list some of the ways in which siRNAs and miRNAs regulate genes.

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Briefly list some of the ways in which siRNAs and miRNAs regulate genes.

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Answer 1

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In eukaryotes siRNA (small interfering RNA) and miRNA (micro RNA) have important role in regulation of gene expression.

Longer segments of dsRNA cleaved by Dicer to form siRNA which assembles into RISC( RNA induced silencing complex) and forms complementary base pairing with targeted mRNA leading to heterochromatisation or degradation of mRNA.

miRNA mainly involved in translation inhibition.

. 1) mRNA degradation pathway - Nucleus Cytoplasm MAG AAA АААА MRNA tronscription MIRISC SIRISC നീG BiscLARA m7G AAAA R. MRNA c 2) mRNA tronstation inhibition by miRNA miRNA biods with complementary region of MRM through RISC, Bomplex inhibits translati

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Briefly list some of the ways in which siRNAs and miRNAs regulate genes.

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