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Following intensive exercise, which of the following would be expected to occur? A.Increased production of 2,3-BPG...

Following intensive exercise, which of the following would be expected to occur?

A.Increased production of 2,3-BPG

B. Decreased hemoglobin affinity for oxygen

C. Allosteric inhibition of hemoglobin via binding of H+ ions

D. All of the above

2. A high concentration of H+ ions will have what kind of effect on the hemoglobin oxygen dissociation curve?

a - A shift to the right

A shift to the left

b- No effect

c- It is not possible to predict with the limited information provided.

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Answer #1

1) The answer will be -(D) All of the above.

Intense exercise leads to elevated levels of 2,3- BPG. This increased level stabilizes the T state conformation which in turn makes it difficult for oxygen to bind to hemoglobin and are hence released to adjacent tissues. Thus, it causes allosteric inhibition of hemoglobin via binding of H+ ions.

2) The oxygen-hemoglobin dissociation curve plots the proportion of hemoglobin in it's oxygen-laden form on the Y-axis ( vertical axis) against the prevailing oxygen tension on the X axis ( horizontal axis). This curve makes us understand how our blood carries and releases oxygen to the surrounding cells. The curve shifts towards the right.Right shift shows decreased affinity of hemoglobin towards oxygen which may be caused due to high body temperature, increase in concentration of H+ ions, 2,3- BPG ( biphosphoglycerate) concentration or high carbon dioxide concentration. Hence, the correct answer is - (a) shift to the right.

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