Problem

When working out genetics problems in this and succeeding chapters, always assume that mem...

When working out genetics problems in this and succeeding chapters, always assume that members of the P1 generation are homozygous, unless the information or data you are given require you to do otherwise.

A “wrongful birth” case was recently brought before a court in which a child with Smith−Lemli−Opitz syndrome was born to apparently healthy parents. This syndrome is characterized by a cluster of birth defects including cleft palate, and an array of problems with the reproductive and urinary organs. Originally considered by their physician as having a nongenetic basis, the parents decided to have another child, who was also born with Smith−Lemli−Opitz syndrome. In the role of a genetic counselor, instruct the court about what occurred, including the probability of the parents having two affected offspring, knowing that the disorder is inherited as a recessive trait.

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