Question

Draw the structure of the major product of each step in the following three-step synthesis. As a start, one benzene ring is drawn for you in each product.

Answer 1

Concepts and reason

The organic reaction is a type of chemical reaction in which one functional group can be converted to other. These conversions can be achieved through wide variety of reagents..

Reagents play a vital role in chemical reactions to undergo functional group transformations. Each reagent plays a different role in the chemical reactions.

Fundamentals

Friedel–Crafts acylation:

In this reaction, an acyl halide reacts with a Lewis acid and generates an electrophile that attacks the benzene ring and forms an acyl-substituted benzene ring.

The general reaction scheme is given below:

Benzylic carbon oxidation:

In this reaction, a benzylic carbon with at least one hydrogen atom is oxidized to a carboxylic group.

The general reaction scheme is given below:

Bromination:

A bromination reaction is the addition of a bromine atom on a molecule through electrophilic substation mechanism. The reagent is and generates ion as an electrophile that reacts with a nucleophilic centre on the benzene ring. The selectivity of substitution on the benzene ring depends on the type of substituent present on it.

The general reaction scheme is given below:

The mechanism for the attack of electrophile is given below:

Conversion for the benzylic oxidation is given below:

Generation of the electrophile is given below:

Ans:

The structures of the major products for the three-step synthesis are