7. Retrosynthetic Analysis a. There are TWO different combinations of the Grignard reagent and carbonyl that...
7. Retrosynthetic Analysis: a. There are two different combinations of the Grignard reagent and carbonyl that can be used to make the product below. Think about TWO ways to make the product, listing the carbonyl and Grignard reagent in the designated boxes. Carbonyl on Grignard Reagent or 2H40 2. H.O Carbonyl Grignard Reagent b. There are THREE different combinations of the Grignard reagent and carbonyl that can be used to make the product. Please draw the three possible cominations of...
Tertiary alcohols with two identical alkyl groups attached to the alcohol carbon can be made either from an ester and two moles of a Grignard reagent, or from a ketone and one mole of a Grignard reagent. Use retrosynthetic analysis to suggest one path of each type to synthesize 1,1-diphenyl-1-propanol. (Click and drag the appropriate image to the correct position in the following reactions.)
?? Three reactions between a Grignard reagent and a carbonyl compound are given below. Draw the main organic product for each reaction and indicate if H+ or H- is needed to complete each reaction. (The starting material structures are provided in the answer fields as a starting point for your drawings.) Ketone reaction Ester reaction Acyl halide reaction Above, keep in mind that two equivalents of the Grignard reagent are utilized. What is the intermediate product resulting from the addition...
1. (6 pts) Provide two different syntheses for 1,1-diphenyl-1-butanol starting from a carbonyl compound and using a Grignard reagent. Synthetic Route 1: carbonyl Grignard reagent a) THE b) H30* work up 1,1-diphenyl-1-butanol Synthetic Route 2: carbonyl Grignard reagent a) THF b) H30* work up ОН 1.1-diphenyl-1-butanol 2. (3 pts) The use of Grignard reagents requires scrupulously dry aprotic solvents such as diethyl ether or tetrahydrofuran. Please explain why the solvents need to be scrupulously dry. To support your reason, show...
Give three different sets of reagents (a carbonyl compound and a Grignard reagent) that could be used to prepare the following compound. OH CH3-C-CH2CH3 CH3 Check all that apply Check all that apply. CH3 CH2 COCHg and CH3 MgBr CH, CH2 COCH3 and 2CH3 MgBr CH3 CH2 C CH3 and CH3 MgBr CH3 C CH3 and CH3CH, MgBr 0 CH3 C OCHZ and CH3CH, MgBr CH3CH, C CH3 and 2CH3 MgBr Submit Previous Answers Request Answer
III. Grignard Reagents. 1. (6 pts) Provide two different syntheses for 1,1-diphenyl-1-butanol starting from a carbonyl compound and using a Grignard reagent. Synthetic Route 1: carbonyl Grignard reagent a) THE b) H3O+ work up OH 1,1-diphenyl-1-butanol Synthetic Route 2: carbonyl Grignard reagent a) THE b) H3O+ work up 1,1-diphenyl-1-butanol
Part A What two distinct combinations of Grignard reagent and aldehyde could be used to prepare the alcohol below? OH Draw the molecules on the canvas by choosing buttons from the Tools (for bonds), Atoms, and Advanced Template toolbars. The single bond is active by default. o 9 C H* 12D 1 EXP. L CONT. 0 1 H + с
Two reactions between a Grignard reagent and a carbonyl compound are given below. Draw the main organic product for each reaction and indicate if H+ or H- is needed to complete each reaction. (The starting material structures are provided in the answer fields as a starting point for your drawings.) Two reactions between a Grignard reagent and a carbonyl compound are given below. Draw the main organic product for each reaction and indicate if H+ or H- is needed to...
Please use retrosynthetic analysis to determine the substrate that gives rise to the following products with the reagents used. If there is no possible substrate, please state so and briefly explain why there is no substrate that will give rise to the reaction. Nacht ОН ہ OH 1) LAH Ý 2) H₂O 11. Hint: This is an intramolecular grignard reaction Ý Please listen to the short lecture on Naming Carbonyl Containing compounds before attempting this next section. Once you are...
i need help with the prelab questions please Grignard reagent THE GRIGNARD REAGENT-PREPARATION AND REACTION In this experiment, you will prepare a Grignard reagent, phenyl magnesium bromide, from bromobenzene and magnesium metal. The Grignard reagent will then react with methyl benzoate to form triphenylmethanol. Introduction Grignard reagents, such as organomagnesium halides, were discovered in 1910 by French chemist Victor Grignard. The Grignard reaction is one of the most general methods for carbon- carbon bond formation in all of organic chemistry....