Question

Question 1 FLAG QUESTION Select the approprate BUD assignment for an opened Multi-Dose Vial (MDV). Currently selected: A A 28 days B 1 day C 30 days D 3 days

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Answer 1

1. Appropriate BUD assignment for an opened multi-dose vial(MDV)

Answer. 28days

Multi-dose vials contain medicine for more than one dose. These contain preservatives to prevent the growth of bacteria. Multi-dose vials should be used for a single patient. If the multi-dose vials once opened, should be discarded within 28 days, or else if it has not been opened then discard it according to its date of expiry.

The other options given are not appropriate.

2. Statement true regarding single-dose vial is:

Answer: BUD is within 6 hours when opened or punctured in an ISO 5 environment.

Single-dose vials are used for a single patient for a single dose. BUD( Beyond Use Date ) is different from the expiry date. A single dose vial that has been opened or punctured in an ISO 5 environment should be used within 6 hours, whereas a single dose vial opened or punctured outside an ISO 5 environment should be used within 1 hour.

3. Compounding of a TPN including all sterile products would be considered low-risk preparation.

Answer: False

Compounding medicines is a process of mixing and combining different elements of drugs prescribed by the physician for a specific individual. All the health care professionals compounding and dispensing the medicines are responsible to prepare the sterile product and have the correct dosage of each element. Theses compounded medicines are classified into three groups depending on their potential risk of being contaminated by microbes: low risk, medium risk, and high risk. TPN including all sterile products are considered to be medium risk preparation.

4. Compounding conditions that categorize a compound as low risk for contamination

Answer: the compounding involves the only transfer, measuring and mixing manipulation using not more than 3 commercially manufactured packages of sterile products and not of one sterile vial or bag.

The low-risk compounding products are made aseptically by using only sterile products and in ISO 5 or even higher quality of the environment. Thes are transferred, measured and mixed with closed and sealed packaging systems. These medicines should not be stored for more than 48 hours at room temperature or for not more than 14 days at a cold temperature. Example: 1 gm of cefazolin.

6. The compatibility of calcium and phosphate salts in PN admixtures is a concentration-dependent phenomenon

Answer: True

The risk of calcium and phosphate salts to precipitate in PN admixtures is when the concentrations of the calcium and phosphate salts are less as compared to the IV fluids. Calcium and phosphates are essential nutrients in parenteral nutrition for a neonate.