Question

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True or false 1) - L Apoptosis can occur after the ATP harvesting capability of a cell is affected. 2) - Intrinsic and extrinsic apoptotic pathways converge with activation of caspase 3. The intrinsic apoptotic pathway requires activation of cell surface receptors called death receptors. 4) or Apoptosis is required for the normal development of many organs. Hypoxia tends to cause increase Ca++ levels which in turn activate enzymes that break down cellular structures. 6) Atrophied cells are dead cells. 7) The positive predictive value of a test gives you a statistical estimate of how well a test can detect a disease even when the signs and symptoms of this decease are very few.

Answer 1

1. False. Apoptosis is a programmed call death involving call shrinking process. Decrease in ATP induced necrosis and not apoptosis. Apoptosis is APT dependent process.
2. True. In  intrinsic pathway , Cascade 3 is activated by Caspase 9 . Cytochrome c is released from mitochondria which then binds to Apoptosis protease activating factor and TAP, which then binds to pro Caspase 9 to create protein complex known as apoptosis. the apoptosis cpeaves pro Caspase 9 to Caspase 9 which in turn activated Caspase 3. In extrinsic pathway, Caspase 3 plays a central role in the transduction of ER apoptotic signals The active Caspase 3 proteolytucally degrade a host of intracellular proteins to carry out the cell death program.
3. False. the extrinsic pathway is activated by extracellular signals binding to call surface death receptors leading to death by apoptosis.
4. True. Apoptosis characterised by typical membrane blabbing, chromatin condensation, DNA fragmentation. this programmed process is playing important role in gametes maturation as well as in embryo development leading to formation of various organs.