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How would you draw the most stable conformation of trans-1-chloro-2-fluorocyclohexane? Axial chlorine on C-1, Axial fluorine

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Answer #1

1) Equatorial chlorine on C-1, Equatorial fluorine on C-2

Equatorial Chlorine on C-1, Equatorial Fluorine on C-2

If both F and Cl are present in equatorial position gives more stable conforms and avoid 1,3-diaxial interactions.

2) Equatorial ethyl group on C-1, Axial methyl group on C-4

Ethyl group on equatorial C-1, Methyl group on axial C-4

The bulky ethyl group on equatorial gives more stable conforms, avoid 1,3-diaxial interactions.

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