Question

A CD133+ cell indicates

Select one:

a. The cell is fully differentiated

b. The cell is cancerous

c. The cell is a progenitor or stem cell

d. The cell is undergoing mitosis

This is all the information I have

Answer 1

B

CD133, also known as prominin-1, is a pentaspan transmembrane glycoprotein that localizes to membrane protrusions such as microvilli and in the apical surface of some epithelial cells. Expression of CD133 in cancer-initiating cells has been reported in several tumor types including hematopoietic malignancies and solid tumors such as retinoblastoma, glioblastomas, prostatic adenocarcinomas and kidney carcinomas.CD133 was recently identified for breast CSCs in cancer cell lines generated from Brca1Δexon11/p53+/− mouse mammary tumors. It was found that 2–4% of CD133+ cells in multiple breast cancer cell

CD133 (also known as AC133 and prominin-1) is the most frequently used cell surface antigen to detect and isolate CSCs from various solid tumors [23], including brain, colon, pancreas, prostate, lung, and liver.