Show the mechanism for the activation of N-protected valine by DCC (dicycloxeylcarbodiimide) followed by addition of...
Show the mechanism for the activation of N-protected valine by DCC (dicycloxeylcarbodiimide) followed by addition of C-protected serine. Use t-BOC group for amino group protection and ethyl ester for carboxylic group protection. (10 marks)
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Show the mechanism for the activation of N-protected valine by
DCC (dicycloxeylcarbodiimide) followed by addition of...
2) Amines are often protected with the tert-butyloxycarbonyl BOC) group. Show the mechanism of fo...
2) Amines are often protected with the tert-butyloxycarbonyl BOC) group. Show the mechanism of fomation of the BOC protected amine (a carbamate). Be sure to show all bonds formed broken and inclade all intermediates including the appropriate formal charge BOOO Do you expect that the carbamate functional group is more or less reactive than an amide towards nacleophilic addition? Bricfly explain your reasoning The BOC protecting group can be removed under acidic conditions, such as treatment with tnifloroacetic acid (TFA)...
3) Amines are often protected with the tert-butyloxycarbonyl (BOC) group. Show the mechanism of formation of...
3) Amines are often protected with the tert-butyloxycarbonyl (BOC) group. Show the mechanism of formation of the BOC protected amine (a carbamate). Be sure to show all bonds formed/broken and include all intermediates including the appropriate formal charge. Na2CO3 + CO2 + NH NHBOC NaOC(CH3)3 leucine (BOC)20 Do you expect that the carbamate functional group is more or less reactive than an amide towards nucleophilic addition? Briefly explain your reasoning amide carbamate The BOC protecting group can be removed under...
5 Synthesis alactone FECH ANH2 IZ correct (trifluoroacetic acid, TFA ETFA N-BOCzo N73 protection HL NH-BOC/...
5 Synthesis alactone FECH ANH2 IZ correct (trifluoroacetic acid, TFA ETFA N-BOCzo N73 protection HL NH-BOC/ ANH-BOC V C amine is not strong enough to reach with the ester (H₂N NaOH H2O acid workup NH-BOC Scheck to H2O make sure you need a carboxylic acid to use Doc the correct Jo Stereochemistry in all in of your intermediales ex DCC? * Homoserine lactone . Formation - Lactone i 915 d0y
2. The structure of the solid phase Wang resin linker and the first amino acid that we will use i...
2. The structure of the solid phase Wang resin linker and the first amino acid that we will use in this lab is shown below Fmoc first amino acid linker a) (1 pt) If the resin has 0.72 mmol/g of this linker on the surface of the beads, and you use 300 mg of resin for the reaction, how many mmol of linker do you have? b) (3 pts) All peptides will use alanine at the C-tenminus (position 1), Fmoc-L-valine...
The proton nmr and the infrared spectra of DCC, DMAP, DCU, the product and the nmrs...
The proton nmr and the infrared spectra of DCC, DMAP, DCU, the
product and the nmrs of the starting materials and products are
shown. These are labeled Compounds A, B and C. a.Which nmr is the
product?
b. Which is the nmr of the starting material?
c. What is the mixture of compounds shown as compound C?
tert-Butyl Ethyl Fumarate DCC, DMAP, CHCI OH Chemical Formula: C,H,O Chemical Formula: CH 0 Molecular Weight: 144.13 Molecular Weight: 74.12 Chemical Formula: CH...
(C) Protonation of alkene to form a carbocation followed by addition of bromide ion (D) Addition...
(C) Protonation of alkene to form a carbocation followed by addition of bromide ion (D) Addition of the proton to one face of the alkene with simultaneous delivery of a bromide ion from a different molecule of H-Br. 11. Which compound is the strongest nmucleophile for reaction of methane methanesulfonate (CHOS0.CH) in methanol at room temperature? (You may assume that everything is soluble in methanol) (A) potassium bromide (B) cesium iodide (C) sodiam chloride (D) lithium flaoride 12. Which proton...
2. (a) (10 marks) Suppose A is an n x n real matrix. Show that A...
2. (a) (10 marks) Suppose A is an n x n real matrix. Show that A can be written as a sum of two invertible matrices. HINT: for any l ER, we can write A = \I + (A – XI) (b) (10 marks) Suppose V is a proper subspace of Mn,n(R). That is to say, V is a subspace, and V + Mn,n(R) (there is some Me Mn,n(R) such that M&V). Show that there exists an invertible matrix M...
2. (a) (10 marks) Suppose A is an n x n real matrix. Show that A...
2. (a) (10 marks) Suppose A is an n x n real matrix. Show that A can be written as a sum of two invertible matrices. HINT: for any l ER, we can write A = \I + (A – XI) (b) (10 marks) Suppose V is a proper subspace of Mn,n(R). That is to say, V is a subspace, and V + Mn,n(R) (there is some Me Mn,n(R) such that M&V). Show that there exists an invertible matrix M...
2. (a) (10 marks) Suppose A is an n x n real matrix. Show that A...
2. (a) (10 marks) Suppose A is an n x n real matrix. Show that A can be written as a sum of two invertible matrices. HINT: for any XER, we can write A= XI + (A - XI) (b) (10 marks) Suppose V is a proper subspace of Mn.n(R). That is to say, V is a subspace, and V #Mnn(R) (there is some Me M.,n(R) such that M&V). Show that there exists an invertible matrix M e Mn.n(R) such...
____ 1. The diagram below represents serine, a polar, uncharged amino acid. Which functional group gives...
____ 1. The diagram below represents serine, a polar, uncharged
amino acid. Which functional group gives serine its
distinct property?
a. H3
b. CH2OH
c. –H
d. COO–
____ 2. The monomers shown below are monomers for which of the
following natural polymers?
a. polysaccharides
b. plastics
c. DNA
d. proteins
____ 3. Which of the following processes illustrates the production
of a protein?
a. specific code for amino acids --> amino acid chain -->
gene --> DNA --> specific...
2) Amines are often protected with the tert-butyloxycarbonyl BOC) group. Show the mechanism of fomation of the BOC protected amine (a carbamate). Be sure to show all bonds formed broken and inclade all intermediates including the appropriate formal charge BOOO Do you expect that the carbamate functional group is more or less reactive than an amide towards nacleophilic addition? Bricfly explain your reasoning The BOC protecting group can be removed under acidic conditions, such as treatment with tnifloroacetic acid (TFA)...
3) Amines are often protected with the tert-butyloxycarbonyl (BOC) group. Show the mechanism of formation of the BOC protected amine (a carbamate). Be sure to show all bonds formed/broken and include all intermediates including the appropriate formal charge. Na2CO3 + CO2 + NH NHBOC NaOC(CH3)3 leucine (BOC)20 Do you expect that the carbamate functional group is more or less reactive than an amide towards nucleophilic addition? Briefly explain your reasoning amide carbamate The BOC protecting group can be removed under...
5 Synthesis alactone FECH ANH2 IZ correct (trifluoroacetic acid, TFA ETFA N-BOCzo N73 protection HL NH-BOC/ ANH-BOC V C amine is not strong enough to reach with the ester (H₂N NaOH H2O acid workup NH-BOC Scheck to H2O make sure you need a carboxylic acid to use Doc the correct Jo Stereochemistry in all in of your intermediales ex DCC? * Homoserine lactone . Formation - Lactone i 915 d0y
2. The structure of the solid phase Wang resin linker and the first amino acid that we will use in this lab is shown below Fmoc first amino acid linker a) (1 pt) If the resin has 0.72 mmol/g of this linker on the surface of the beads, and you use 300 mg of resin for the reaction, how many mmol of linker do you have? b) (3 pts) All peptides will use alanine at the C-tenminus (position 1), Fmoc-L-valine...
The proton nmr and the infrared spectra of DCC, DMAP, DCU, the
product and the nmrs of the starting materials and products are
shown. These are labeled Compounds A, B and C. a.Which nmr is the
product?
b. Which is the nmr of the starting material?
c. What is the mixture of compounds shown as compound C?
tert-Butyl Ethyl Fumarate DCC, DMAP, CHCI OH Chemical Formula: C,H,O Chemical Formula: CH 0 Molecular Weight: 144.13 Molecular Weight: 74.12 Chemical Formula: CH...
(C) Protonation of alkene to form a carbocation followed by addition of bromide ion (D) Addition of the proton to one face of the alkene with simultaneous delivery of a bromide ion from a different molecule of H-Br. 11. Which compound is the strongest nmucleophile for reaction of methane methanesulfonate (CHOS0.CH) in methanol at room temperature? (You may assume that everything is soluble in methanol) (A) potassium bromide (B) cesium iodide (C) sodiam chloride (D) lithium flaoride 12. Which proton...
2. (a) (10 marks) Suppose A is an n x n real matrix. Show that A can be written as a sum of two invertible matrices. HINT: for any l ER, we can write A = \I + (A – XI) (b) (10 marks) Suppose V is a proper subspace of Mn,n(R). That is to say, V is a subspace, and V + Mn,n(R) (there is some Me Mn,n(R) such that M&V). Show that there exists an invertible matrix M...
2. (a) (10 marks) Suppose A is an n x n real matrix. Show that A can be written as a sum of two invertible matrices. HINT: for any l ER, we can write A = \I + (A – XI) (b) (10 marks) Suppose V is a proper subspace of Mn,n(R). That is to say, V is a subspace, and V + Mn,n(R) (there is some Me Mn,n(R) such that M&V). Show that there exists an invertible matrix M...
2. (a) (10 marks) Suppose A is an n x n real matrix. Show that A can be written as a sum of two invertible matrices. HINT: for any XER, we can write A= XI + (A - XI) (b) (10 marks) Suppose V is a proper subspace of Mn.n(R). That is to say, V is a subspace, and V #Mnn(R) (there is some Me M.,n(R) such that M&V). Show that there exists an invertible matrix M e Mn.n(R) such...
____ 1. The diagram below represents serine, a polar, uncharged
amino acid. Which functional group gives serine its
distinct property?
a. H3
b. CH2OH
c. –H
d. COO–
____ 2. The monomers shown below are monomers for which of the
following natural polymers?
a. polysaccharides
b. plastics
c. DNA
d. proteins
____ 3. Which of the following processes illustrates the production
of a protein?
a. specific code for amino acids --> amino acid chain -->
gene --> DNA --> specific...
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