Question

Val-Tyr is a dipeptide consisting of valine and tyrosine amino acid that exhibits antihypertensive activity. Show the mechanism (including electron pushing arrows) for the phophorylation of Val-Tyr by ATP. Remember, you can use R groups to simplify complex molecules.

ОН R1 NH3 АТР Val-Tyr

Answer 1

:0 let - R co-H :0 PR 1 Reaction 10. ra Mechanism LLC o + 0 0 * V OSO P ProrR, + OS! Actas nucleophile 03 DP -0 LO 0 tp 1. Sirk + Örö t :. (ADP) NH3 Phosphorylated val-Top