Question

Usšification: Bone Formation and Growth in Length 12. Compare and contrast events occurring on the epiphyseal and diaphyseal faces of the epiphyseal plate. Epiphyseal face: Diaphyseal face: These tears lead to inflammation of the periosteum. Considering the type of tissue found in the periosteum, which cells do you 13. The pain in the leg that is referred to as "shin splints" is often caused by microtears in the periosteum and perforating fibers. think would be most involved in the repair process? 14. h rickets, the bones are not properly calcified. Which treated bone in Activity 2 most closely resembles the In a child wit bones of a child with rickets? Why? 15. Achondroplasia is a type of dwarfism in which the long bones stop growing during childhood, resulting in limbs that are disproportionately shorter than the torso. This genetic disorder is characterized by deficiencies in the epiphyseal plate that include a low number of chondrocytes and inability of chondrocytes to enlarge. Which zones do you think would be most affected by this disorder, and why?

Answer 1

12. ANS:

Epiphyseal face: In long bone formation and growth (particularly in length), the medulla, cavity gets larger and the chondroblasts lay new cartilage matrix on the epiphyseal face of the epiphyseal plate. The cartilage replaced by bony spicules on the side facing the medullary cavity. This process continues throughout adolescence until the entire epiphyseal plate is replaced by bone.

Diaphyseal face: Meanwhile, on the diaphyseal face, the cartilage cells from the proliferation zone age and begin to enlarge. Also on the diaphyseal face, there is a calcification zone where the cartilage cells die, cartilage matrix calcifies and begins to deteriorate. Blood vessels invade the cavity and begin the endochondral ossification process, thereby convening cartilage matrix into osseous tissue, or bone.

13. ANS: Periosteum is thin connective tissue layer covering the bone. The most involved cell during in the repair process is…
Fibroblasts
Chondroblasts
Osteoblasts
Osteoclasts

14. ANS: In this condition the bone was treated with acid, it is because in the presence of acid the calcium phosphate can dissolved. It can make bones less rigid and prone to deformation.

15. ANS: In the zone of hypertrophy, condrocytes increase in size. In achondroplasia inability of chondrocytes to enlarge is seen so this zone is affected. In the zons of proliferation, number of chondrocytes increase. In achondroplasia, their number decreases so, this zone is also affected.

So the Proliferation and Hypertrophic Zones are mostly affected by this disorder.

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