Question

18. A deficiency in vitamins B6 and B12 could lead to poor clearance of what endogenous metabolite associated with cardiovascular disease? 19. Pyruvate is an alpha-keto acid and is one of the end products of glycolysis. The energy stored in this molecule is used to generate NADH, FADH2, and GTP in the TCA cycle. However, before it gets there, pyruvate must undergo a few metabolic steps in the pyruvate dehydrogenase complex (e.g. oxidative decarboxylation) on its way to becoming acetyl-CoA. Name at least three vitamins that help to facilitate reactions in this complex.

Answer 1

18)Deficiency of these vitamins leads to poor clearance of homocysteine, which is associated with cardiovascular disease.

19)Three vitamins which help to facilitate the reaction in the PDH (Pyruvate dehydrogenase) complex are

Thiamine

Riboflavin

Pantothenic acid