Question

Question 10 (1 point) Identify the chemical reasons for the large negative Delta G associated with hydrolysis of ATP to ADP + P. (Select all that apply, marks will be deducted for incorrect responses) a) The ability of the phosphate group of ATP to participate in a variety of reactions with common functional groups. O b) Release of charge repulsion among the negative charges c) ionization of ADP2-to form ADp3- and H+ d) The presence of the enzyme pyrophosphatase which hydrolyzes PP, to 2 P. e) The ability to tranfer a phosphate, pyrophosphate or an adenylate group to the reacting substrate. f) Resonance stabilization of the inorganic phosphate product

Answer 1

The chemical reasons for the large negative Delta G associated with the hydrolysis of ATP to ADP + Pi :

a) The ability of the phosphate group of ATP to participate in a variety of reactions with common functional groups - is true statement and involve in biological reactions that particularly have large positive standard free energy change.

b) Release of charge repulsion among the negative charges - is also true statement because there are four negative charges in close proximity in one another and naturally repel each other by charge separation that makes ATP molecule unstable.

c) Ionization to ADP^-2 to form ADP^-3 and H⁺ - is true statement because the product of hydrolysis ADP^-2 that immediately ionises and produce hydrogen ion into a medium of low pH.

d) The presence of enzyme pyrophosphatase which hydrolyzes PPi to 2Pi - is true statement pyrophosphate transfer is present at beta position of ATP molecule and transfer 2 inorganic phosphates.

e) The ability to transfer a phosphate, pyrophosphate or an adenylate group to the reacting substrate - is true statement adenyl transfer or phosphate transfer or pyrophosphate transfer have large negative standard free energy

f) Resonance stabilization of the inorganic phosphate product - is also true statement resonance stabilization of inorganic phosphate Pi is greater than that of ATP