Question

Define and explain the term coagulation and coagulant. (pls do not take internet answers)

Answer 1

Coagulation is nothing but blood clotting this is a complex process that also involves a positive feedback system and only a few stages are included here the factors involved or I will list it later their numbers represents the order in which they were discovered and not the order of participation in the loading process ok blood clotting results in formation of an insoluble threadlike mesh of five brain which traps blood cells and is much stronger than the rapidly form of platelet plug. In the final stage of this process prothrombin activator acts as on the plasma protein prothrombin converting it to thrombin

Thrombin then acts on another plasma protein fibrinogen and convert it to fibrin prothrombin activator can be formed by two process which often occurs together the actions extrinsic and intrinsic Pathways the extrinsic pathway occurs rapidly within seconds when there is tissue damage outside the circulation damaged tissue releases a complex of chemical called thromboplastin or tissue factor which initiates coagulation the intrinsic pathway is slower 3 26 minutes and is confined to the circulation it is triggered by damaged to a blood vessel lining endothelium and the effects of platelets adhering to eat after a time the clots in squeezing out serum a clear sticky fluid that consists of Plasma from which clotting factors have been removed.

Blood clotting factors number 1.fibrinogen

2 prothrombin

3 tissue factor

4 calcium

5 labile factor,proaccelerin,Ac-globulin

There is no 6 factor

7 stable actor ,proconvertin

8 antihaemophilic globulin(AHG),

9 Christmas factor ,plasma thromboplastin component (PTA)antihemophilic factor B

10 stuart prower factoe

11 plasma thromboplastin antecedent(PTA) antihemophilic factor c

12 hageman factor

13 fibrin stabilising factoe

Vitamin K is essential for synthesis of factors 2 7 9 10. Ireff book 9th edition Ross and Wilson Anatomy and Physiology.

Coagulant is a substance that causes blood to clot.