For this reaction, we will use two step synthesis. The answer also needs you to draw the isolable intermediates
Step 1: Bromination
The bromine will be substituted at Meta position due to Meta directing tendency of -CHO group.
Step 2: Reduction using NaBH4. The aldehyde will be reduced to alcohol
Step 3: Converting alcohol to chloroalkane by PCl5
Step 4: Conversion to Phosphorus Ylide
Step 5: Wittig reaction and addition of Cyclohexanone
Here, all the products formed in intermediate steps are isolable intermediates. This method has been chosen because in the last step Cyclohexanone is easily available compound. Otherwise, one could have also achieved this conversion in two steps by using Bromocyclohexane along with PPh3 and BuLi i.e. by Wittig reaction in the step 2 itself.
For that mechanism, Step 1 will remain as it is and step 2 will be,
1. Propose reagents and conditions for the following multistep syntheses. You may use any reagents necessary....
Propose a reasonable synthetic route for each of the following multistep syntheses. Show all isolable intermediates. D. E.
3. Propose reasonable syntheses of each of the following compounds from the given starting materials. You may use any other readily available alkyl halides, solvents and reagents as necessary. More than one step is necessary. Show all intermediates, reactions, reagents and conditions clearly. It is not necessary to show the mechanism. HCECH HCECH , X HCECH HC=CH M H OHC (30 marks)
What are the following syntheses for each compound? 7. Propose a synthesis for each of the following compounds using the indicated starting material. You may use any organic compounds, inorganic compounds, organometallic compounds, or solvents of your choice. Do not show any reactive intermediates, mechanisms, or transition states, but be sure to show each isolable compound along your synthetic route. осон steps H₂C (ra (racemic) Hoc OH Hac CH3 сна N-OH steps
b. Page 4 (Question 4 continued) Propose reasonable syntheses for the following indicated compounds and using any other necessary orga Show all intermediates formed to receive full credit ÇO2H I NO₂ for the following compounds beginning with the ng any other necessary organic or inorganic reagents. CHE SO3H OCH2CH3 [3% +6% marks] c. Outline the synthesis of the following compound using either the aceu meester synthesis method. Draw the structure of the starting material and show all intermediates, reagents and...
Page 4 Propose reasonable syntheses for the following compo compounds and using any other necessary organic intermediates formed to receive full credit. Assume separated. ng compounds beginning with the indicated organic or inorganic reagents. Show all sume any isomers formed can easily be [3% +6% marks] c. Provide any required reagents and give the stru following synthetic scheme. If more than one reaga steps. ve the structures of the intermediates in the one reagent is required, please number the Bra,...
Show how the following compound could be prepared from 1-butyne. You may use any necessary reagents. You must show all stable intermediates formed along the way and all necessary reagents used (20 points). multiple steps!
Show how the following compound could be prepared from 1-butyne. You may use any necessary reagents. You must show all stable intermediates formed along the way and all necessary reagents used (20 points). multiple steps! Br
Show how the following compound could be prepared from ethyne. You may use any necessary reagents. You must show all stable intermediates formed along the way and all necessary reagents used (10 points). OS multiple steps! Hinh .
Need help understanding what compounds to use when doing multistep syntheses. 5. (Multistep synthesis) For each of the following multistep syntheses, provide an efficient multistep synthesis of the target compound from the starting compound. More than one reaction is required for this synthesis. You may use any inorganic compounds that you need. For cach functional group transformation, give all necessary reagents, solvents, and catalysts; give a structural formula of the organic reactant and the major organic product(s). Show stercochemistry appropriately...
1.) Propose a synthesis for the following general reactions. You may use any other organic or inorganic reagents needed. For each step, show the reagents used and the intermediate formed (Note: I do not need to see any arrow-pushing, only starting materials, reagents, intermediates, and the final product) a.) For each aromatic ring, you must start with a plain benzene. он он CI он