Question

27. Which of the following agents is best classified as a mu-opioid receptor antagonist with restricted ability to cross the blood-brain barrier? a. Naltrexone b. Methylnaltrexone C. Alosetron d. Loperamide 28. What is the major reason behind so many formulations of aminosalicylate drugs? a. Pharmacogenetic factors associated with IBD b. To target different anti-inflammatory mediators C. Delivery of drug to different anatomical locations

Answer 1

Question 27: answer is b,: methylnaltrexone. It is peripheral acting u opiod antagonist that acts on GI tract to reduce opiod induced constipation. Question 28: answer is b: to Target different anti inflammatory mediator.