The conversion of 12 into Prozac is carried out by treating with cyanogen bromide. Propose a...

Question

Question

The conversion of 12 into Prozac is carried out by treating with cyanogen bromide. Propose a mechanism for this transformation. CF3 CF3 H Prozac

Answer 1

Answer #1

It is a name reaction , which is called von Braun Reaction in which a tertiary amine reacts with cyanogen bromide to an organocynamide.

The reaction mechanism is consists of two nucleophilic substitution.

NC- con Hydrolysis Decarboxylation -con W

Answer 2

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