Homework Answers
The reaction , that will actually occur is -
By using LiOR , we expect a simple substitution , but for nucleophilic substitution , condition needed is stronger .
Even , with these given reagents, the expected product would need a ipso substitution mechanism, that is not possible here . We need to make the leaving group more strong , only then , this reaction can occur.
Thus , the way of making this product will be -
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Nucleophilic sub stitution (3 points) The following reaction will not occur as shown. Explain the following:...
Part 2. Nucleophilic substitution The reaction below is a nucleophilic substitution. Answer the following questions OH...
Part 2. Nucleophilic substitution The reaction below is a nucleophilic substitution. Answer the following questions OH NaOH MeOH Br 1. What is the intermediate? (4 pts) 2. What is the product? Pay attention to stereochemistry where appropriate. (4 pts) Part 3. Integrated question The reaction below has been asked in our lecture. What are reagents required to complete the synthesis? (Hints: two steps) (6 pts) SCH3
21) Provide the correct product(ss) for the reactionn conditions shown below. If no reaction will occur,...
21) Provide the correct product(ss) for the reactionn conditions shown below. If no reaction will occur, state "no reaction" and briefly explain why for full credit. For products that have stereochemistry clearly show it where necessary. (4 points each; 20 points total) КОН B) Br Н-о NaOC(CH3) D) Br CH3OH NaC Он
Determine the correct order of steps that will occur for the possible reaction shown below. To en...
Determine the correct order of steps that will occur for the possible reaction shown below. To enter your answer, use the numbers that are adjacent to the correct descriptions in the correct order. For example, if you felt that 1, followed by 2 and then 3 reflects the correct ordering of reaction steps, then you would enter: 1, 2,3 for your answer. Do so even if the reaction sequence includes two distinct steps (with two different conditions/reagents). In other words,...
Determine the correct order of steps that will occur for the possible reaction shown below. To en...
Thank you!
Determine the correct order of steps that will occur for the possible reaction shown below. To enter your answer use the numbers that are adjacent to the correct descriptions in the correct order. For example, if you felt that 1, followed by 2 and then 3 reflects the correct ordering of reaction steps, then you would enter: 1, 2, 3 for your answer. Do so even if the reaction sequence includes two distinct steps (with two different conditions/reagents)....
3) Gilman reagents are a type of organocuprate which are able to provide nucleophilic carbons for...
3) Gilman reagents are a type of organocuprate which are able to provide nucleophilic carbons for a 1,4 conjugated addition on a,B-unsaturated carbonyls (see below). Following the addition, an acidic workup protonates the anionic intermediate to yield the product shown. a. Draw the mechanism that occurs between the anionic carbon nucleophile and the cyclic ketone electrophile. The mechanism should use 3 arrows. Show the intermediate following the addition in the box below. Indicate charges Explain why the nucleophilic carbon attacks...
Determine the correct order of steps that will occur for the possible reaction shown below. To en...
Determine the correct order of steps that will occur for the possible reaction shown below. To enter your answer, use the numbers that are adjacent to the correct descriptions in the correct order. For example, if you felt that 1, followed by 2 and then 3 reflects the correct ordering of reaction steps, then you would enter: 1, 2, 3 for your answer. Do so even if the reaction sequence includes two distinct steps (with two different conditions/reagents). In other...
Why will the following reaction not occur the way that it is described? 3. C Mg...
Why will the following reaction not occur the way that it is described? 3. C Mg The 3-iodopropyne is pointing the wrong direction a. b. An elimination reaction is favored over a substitution. The product of chlorocyclopentane and Mg° is too sterically hindered to add to the 3- iodopropyne. C. d. The 3-iodopropyne contains an acidic hydrogen and cannot be made into a Grignard reagent. Grignard reagents don't react well with alkyl halides. e.
d and SHOWS ures. 3. Consider the following nucleophilic substitution: CH3 CH CH3 CH Br +...
d and SHOWS ures. 3. Consider the following nucleophilic substitution: CH3 CH CH3 CH Br + HBr CH iPrOH (xs) Calculate the theoretical yield of the product if 35.50 grams of the reactant 2- bromomethylcyclohexane is used. a) b) Determine the percent yield if the actual yield is 29.75 grams. 4·The reaction in the isomerization experiment performed has a carbocation intermediate. Explain why carbocation rearrangement does not occur.
What product will be produced by the following reaction? Sect 9.4 Br 1) XS NaNH/NH, Br...
What product will be produced by the following reaction? Sect 9.4 Br 1) XS NaNH/NH, Br 2) H20 Sect 9.5 Predict the product(s) for the following reaction Na NH, Sect 9.7 Predict products for the following reaction 1) Disamylborane 2) HOz, NaOH Draw the alkyne reactant and reagents that could be used to synthesize the following molecule Sect 9.9 Predict the product(s) for the following reaction 1) O, 2) H,0 Suggest necessary reaction conditions for this multi-step conversion Sect 9.12
2. Explain why cycloheptatriene, shown below, will react with an acid to form a carbocation (the...
2. Explain why cycloheptatriene, shown below, will react with an acid to form a carbocation (the tropyllum ion)? 3. Predict the major organic product in the following reaction HBT 4. What is the major product of the following reaction? OH HINO, TO CHÚCH . 5. What is the major product of the following reaction? ME E1,0 2)H,09 6. We learned that the bond dissociation ener() of the highlighted C-H bond in toluene is lower than the DE of the C-H...
Part 2. Nucleophilic substitution The reaction below is a nucleophilic substitution. Answer the following questions OH NaOH MeOH Br 1. What is the intermediate? (4 pts) 2. What is the product? Pay attention to stereochemistry where appropriate. (4 pts) Part 3. Integrated question The reaction below has been asked in our lecture. What are reagents required to complete the synthesis? (Hints: two steps) (6 pts) SCH3
21) Provide the correct product(ss) for the reactionn conditions shown below. If no reaction will occur, state "no reaction" and briefly explain why for full credit. For products that have stereochemistry clearly show it where necessary. (4 points each; 20 points total) КОН B) Br Н-о NaOC(CH3) D) Br CH3OH NaC Он
Determine the correct order of steps that will occur for the possible reaction shown below. To enter your answer, use the numbers that are adjacent to the correct descriptions in the correct order. For example, if you felt that 1, followed by 2 and then 3 reflects the correct ordering of reaction steps, then you would enter: 1, 2,3 for your answer. Do so even if the reaction sequence includes two distinct steps (with two different conditions/reagents). In other words,...
Thank you!
Determine the correct order of steps that will occur for the possible reaction shown below. To enter your answer use the numbers that are adjacent to the correct descriptions in the correct order. For example, if you felt that 1, followed by 2 and then 3 reflects the correct ordering of reaction steps, then you would enter: 1, 2, 3 for your answer. Do so even if the reaction sequence includes two distinct steps (with two different conditions/reagents)....
3) Gilman reagents are a type of organocuprate which are able to provide nucleophilic carbons for a 1,4 conjugated addition on a,B-unsaturated carbonyls (see below). Following the addition, an acidic workup protonates the anionic intermediate to yield the product shown. a. Draw the mechanism that occurs between the anionic carbon nucleophile and the cyclic ketone electrophile. The mechanism should use 3 arrows. Show the intermediate following the addition in the box below. Indicate charges Explain why the nucleophilic carbon attacks...
Determine the correct order of steps that will occur for the possible reaction shown below. To enter your answer, use the numbers that are adjacent to the correct descriptions in the correct order. For example, if you felt that 1, followed by 2 and then 3 reflects the correct ordering of reaction steps, then you would enter: 1, 2, 3 for your answer. Do so even if the reaction sequence includes two distinct steps (with two different conditions/reagents). In other...
Why will the following reaction not occur the way that it is described? 3. C Mg The 3-iodopropyne is pointing the wrong direction a. b. An elimination reaction is favored over a substitution. The product of chlorocyclopentane and Mg° is too sterically hindered to add to the 3- iodopropyne. C. d. The 3-iodopropyne contains an acidic hydrogen and cannot be made into a Grignard reagent. Grignard reagents don't react well with alkyl halides. e.
d and SHOWS ures. 3. Consider the following nucleophilic substitution: CH3 CH CH3 CH Br + HBr CH iPrOH (xs) Calculate the theoretical yield of the product if 35.50 grams of the reactant 2- bromomethylcyclohexane is used. a) b) Determine the percent yield if the actual yield is 29.75 grams. 4·The reaction in the isomerization experiment performed has a carbocation intermediate. Explain why carbocation rearrangement does not occur.
What product will be produced by the following reaction? Sect 9.4 Br 1) XS NaNH/NH, Br 2) H20 Sect 9.5 Predict the product(s) for the following reaction Na NH, Sect 9.7 Predict products for the following reaction 1) Disamylborane 2) HOz, NaOH Draw the alkyne reactant and reagents that could be used to synthesize the following molecule Sect 9.9 Predict the product(s) for the following reaction 1) O, 2) H,0 Suggest necessary reaction conditions for this multi-step conversion Sect 9.12
2. Explain why cycloheptatriene, shown below, will react with an acid to form a carbocation (the tropyllum ion)? 3. Predict the major organic product in the following reaction HBT 4. What is the major product of the following reaction? OH HINO, TO CHÚCH . 5. What is the major product of the following reaction? ME E1,0 2)H,09 6. We learned that the bond dissociation ener() of the highlighted C-H bond in toluene is lower than the DE of the C-H...
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