E. NaCNBH3 reduces the imine into amine.
F. Example for Curtius rearrangement.
G. LiAlH4 reduce the azidei to amine.
VI. Reactions (21 pts) Provide the major product in the following reaction. It as the product...
VI. Reactions (21 pts) Provide the major product in the following reaction. If no reaction occurs, write "NR as the product. Show your work for each step!! Pay attention to Regiochemistry and Stereochemistry! TSCI EtyN 1. CHg-Br (xs) 2. Ag20, H20, A H-CI Et20 Sold lo no? NaBH CN a. NaNg, EtOH b. H20,4 OH 1. SOCI, pyridine 2. NaN, DMF 3. LIAIH, Et20
Two pages 30 1) Provide the structure of the major product for ten of the following fifteen reactions. Assume enough reagent to react with all functional groups capable of reaction. NH NaBH,CN 1) MEB 2)H,0 HO NH NaN, 1) NaNO,, H.SO. NH, 2) HBF. KOH 1) odo H30 opas 1) LiAIH, 2) H.O OH h) NH H,SO H.0, A CN 1 cui Oculi O .-780 Br SOCI, NH 1) CHI (xs) 2) Ag,0,H,O, tion N'HSO, H20 Cu_0 Br corond me...
provide the major product in the following reaction NH2 NaBH3CN a. NaNg, EtOH b. H20, A ОН 1. SOCI2, pyridine 2. NaN3, DMF 3. LIAIH4, Et20
Can you answer them all? Thanks 10. What would be the product of the following reaction sequence? 1. CHJ (excess) 2. Ag O, H2O 3. heat но C. a. (HC)N e. mixture of (c) and (d) d. N CH3 CH3 CHg 11. Which of the following would fail to produce an ester? HO0 RCO H excess EtOH b. 1. DIBAL isopropanol CN C. d. CI 2. HO pyridine e. all of these will yield an ester 12. What would be...
Reactivity of various compounds. Indicate the product of the following reactions. When necessary, pay attention to the stereochemistry of the reagent andnto that of the final product. PROBLEM 2. Reactivity of various compounds. Indicate the product When necessary, pay attention to the stereochemistry of the reagenta product of the following reactions. eagent and to that of the final product! (_) SOCI LOH pyridine Fac он PCIE CH₃ LIAID4 OH Croz /H он NaH он Et20
Provide the MAJOR product(s) for the following reactions. SN2 and E2 reaction will only give one major product (the substitution of elimination product) major product (the substitution or elimin SOCI, Pyridine HCI (excess) Heat Oh ot H2SO4, H20 Nas DMF, 25 °C NaOH H20, 55 °C Br
1. For each of the following reaction state the major product(s). If there is no reaction, state NR. Specify stereochemistry where appropriate. a) H-Br b) SOCI, Py OH c) 1.TsCI/Py 2. NaBr d) PBr3 e) Conc. H2SO4, Heat 制. f) 2. NaOMe 8) 1.TsCI/Py 2. t-BuOK h) H2CrO4
provide the major product in the following reactions ОН TsCI O Et N NH2 1. CHg-Br (xs) 2. Ag2O, H20, A H-CI Et20
organic III. Predict the major product(s) or fill in the reagent(s) for the following reactions. If there is no reaction write NR. (6 points each, 36 points total) Show the correct stereochemistry when needed!! 16 HO H,Cro (excess) -CHO 17 1)0, (2 equiv.) 2) Mezs (2 equiv.) 18 Ph Ph он om Ph Ph 19 1) mCPBA 2) EtONa, EtOH 20 1) LIAIH (excess) 2) H20*, ,0+ 21 1) NaNH, 2) CH,Br 3) HBr (2 equiv.)
Draw the major product(s) or reagents for the following reactions. Pay attention to stereochemistry where appropriate. Put a box or circle around your final answer. 1. NaN Br g. 2. H2 (xs), Pod 1. xs LAH 2. H20 h. NH2 3. ethyl iodide (xs) 1. NaNO2, HC 2. CuCN NH2 3. PhMgBr (xs) 4. Hyo xs LiAI(OR) H 0 1. Br2. FeBr 2. SOCI2. Py NH2 k.