When you conduct a randomized placebo-controlled clinical trial with new treatment group (A) compared with a...
When you conduct a randomized placebo-controlled clinical trial with new treatment group (A) compared with a placebo group (B), which of the following methods can achieve true randomization?
A. Alternating the patients for the new treatment group and the placebo group, for example, ABABABAB
B. Assigning young patients to the new treatment group and old patients to the placebo group
C. Assigning patients in Clinic 1 to the new treatment group and patients in Clinic 2 to the placebo group
D. Using Data and Safety Monitoring Board (DSMB) to issue random number to determine allocation to either new treatment or the placebo group
E. Assigning patients on odd days to the new treatment group and patients on even days to the placebo group
Homework Answers
A alternating like ABABAB achieve true randomisation
- Randomized: The researchers decide randomly as to which participants in the trial receive the new treatment and which receive a placebo, or fake treatment.
- Controlled: The trial uses a control group for comparison or reference. In the control group, the participants do not receive the new treatment but instead receive a placebo or reference treatment.
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