Question

Free heme regulates globin chain production by: Select one: O a. Activating heme-regulated inhibitor (HRD) of translation O b. Inhibiting globin transcription O c. Increasing transcription of globin O d. Exerting a positive effect on heme-regulated inhibitor (HR) of translation

Answer 1

Ans) b. Increasing globin transcription

Explaination:

In addition to serving as a prosthetic group for hemoglobin, heme also regulates the transcription of globin genes through its binding to the transcriptional factor Bach1 during erythroid differentiation.

a. RPI value will change quiker than a corrected reticulocyte count

Explaination:

- In this condition, anemia is caused by increased destruction of RBCs. The bone marrow increases RBC production to compensate, resulting in a high reticulocyte count. Hemolytic disease of the newborn: This condition causes increased RBC destruction, similar to hemolytic anemia described above.