Question

1. Lets compare two lipid bilayer systems: one composed of phospholipids having saturated acyl chains 20 carbons in length, and the other having acyl chains of the same length but with cis double bonds at C-5, C-8, C-11 and C-14. a. Lets assume that all of the head-groups are phosphatidylethanolamine. Draw a representative lipid from each bilayer system. b. Which lipid bilayer system will have the highest Tm? Explain.

Answer 1

0 Lipid bilayer Q000 S 1 118-onelayer and bilayer of Livad Lipid bilayer- 0080808 - Second Layer Lipid O Polar hy drophilic head of the Lipid molecule non polar hydrophobic tail of the lipid molecule NH3 © Phosphatidyl ethanolamine structures -o-Hocteachee linid having safyreefed acylchain of 20 Carbon D20 - -p-o-CH₂CH2 5 9 7 1 0 - 25 13 19 17 15 14 12 10 20 18 16 A . @ Libid molecule having cis double bond at C5, C8, 91, Cly ľo-CH2-CH2 19 17 15 14 12 1 9 8 6 2 1 NH3 4 B 26 Is ] Yob is double bond at Csco, C1, Cly. 3 Melting is a property of packing of molecule in Solid state more properly packing of molecule in Sold solid state lead to an higher metting Temp. Tm Since saturated molecule packed much more effectively than Unsaturated one so saturated libid molecule AS have higher Tm than Unsaturated lipid molecule B