Question

6. The procedure for this lab when actually done specifies refluxing the alkyl halide with the alkoxide base in dry alcohol as the solvent. a. What substance should be missing from a dry reagent? b. Write a reaction equation, using structures, for the reaction that would occur between the substance you mentioned in part a and tert-butoxide and label the acid, base, conjugate acid, and conjugate base in the reaction. c. How would the presence of the conjugate base formed in this reaction affect the ratio of the trans-2-heptene to 1-heptene produced in the reaction, compared to having just tert- butoxide present as the base? Why?

Answer 1

t-Butoxide is a bulky hindered base it gives terminal alkene as a major product aprox 67% .

@ Dry Reagent should't contain water molecule in it. Ho should be absent in dry Reagent, Br 6 Name fayome H H (Base). Trans-hept-2-ene .. Aeld M i-heptene кои J-heptene Dot Bu (Base) Acid Br Br © n m -Br ame Product ҮЕ 7 ome (conjugate Base) (Acid) If ter-Butoxide present as base A will give s-heptene as major product Betr Because it is hindered

While as NaOMe has small size by which it gives more substituted alkene as a major product aprox 57% .