Question

11A) Describe acidity trend in carboxylic acids describing the effects of induction, dipole resonance and proximity using reasonable pKa.

11B) Give any 8 new carbon-carbon bond formation reactions.

UNUTDuy Name: 11. Answer one of the following Describe acidity trend in carboxylic acids describing the effects arboxylic acids describing the effects of induction, dipole resonance and proximity. Use reasonable molecules with reasonable pKa values to support your logic. b. Give any 8 new carbon-carbon bond formation reactions (need name of reaction, reactant, uons (need name of reaction, reactant, reagent, product)

Answer 1

E E : pla 3.75 0.0 Inductive effecte Acidity is increased by electron withdrawing - - I effect on adjacent carbons. The conjugate base in this case is highly stabilised ley the -I effect. Hhon cathoth schon 4.74 less acidic highly acidic Similarly & I effect of Cly destabilises the conjugate lease and decreases the acidity In short, - I increases acidity - t I decreases acidity More the acidity of the acid, lower is the value of the pka. Higher the electronegativity of the substituents, the higher is the acidity of the acid. Scanned with CamScanner

- Dipple Resonance of carboxylic aude . In the conjugate base of the carboxylic acid, the carboxylate ania is highly alabilecid ley resonance Affect In cases where the carboxylate have higher resonance structures, there is an increase in the acidity of the acid CH-il on roton pha - 4.8 pha: 4.2 Benzoic acid has more resonance structions [ resonance in the beentene ring also J -M effect which results in it leeing a stronger aced than cocoon + H2OB - C carboxytate on more acut Can's canner

Date - Proximily effect Electronegative substilúents increase the acidity of the acid and closer the substituent is near the carboxyl group, the higher is the acidity CH CHL CH-com CH chcą woor ce pka 20 pla 4.1 - This is since the inductive effect of a decreases as the separations increases. The closer el is to cool, the better can it stabilise the carboxylaté anion. So cl having higher proximity to cool is a better acid having a pla of 2.8.

OM Carson - carbon bond formatim. 1) Grignard reaction tely eth 2) Hoot a celone tertiary lutyt alcohol exy Mg Br is the grignard reagent anche ay agish CS arscantied with CamScanner

2) Fruidel Grajce Reación o ergth ce To en an Ald catalyst - reflux Acetophenone CH2 woce → acetyl chloride ffffffit ff it Heck Reaction Bronobenzene Pedo, Pd(b) acetale Eton in na 4) 2 er toch 4nn eng the alb. meltry lethancale x-hydroxy acelone Acyloin condensation reaction. This is Scanned with CamScanner

LUUL 5) Clusin condensation 2 en toer . Naoch City Loett 2. Hoot Me 왕애 Ethylacetale (Ethand) och ethy - ethylacetoacetate Diels Alder Reaction cyclohexene tudio - ethylene e dienophite) (diene). .. Ni catalyst ath-anh 7) CH₂ Br + exhz Maßr - melture bromide - Mg Br2 ethana This coupling is called Kumada coupling and uses Ni/pd catalyst Scanned with CamScanner

Date _8) leimar Tiemann Reaction : x ou Chala IH aq kon phenol Salicylaldehyde Chel, is chlorofrom a) Willig reaction. 3 THE R 4 Meetone or aldehyde Substituted formie phoneim glides Substituted - athene teha pzo (teriphenylphosphine oxide) Scanned with CamScanner

Date 10. Wurtz reaction UX a esh Br + ana refy Methyl bromide ertz-Cry+ a NaBr ethane sodiumbromide cs Scanned with CamScanner
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