Question

6. An order is received for a 100 mCi vial of Technetium Tc pertechnetate calibrated for 8:00 AM (0800 hours) to be used at one of the nuclear medicine accounts. The pharmacy must prepare the dose for delivery at 0500. What activity should be dispensed at 0500 to deliver the desired activity? The Half-life of technetium "Tc is 6.02 hours.

Answer 1

1. Remove the central metal disc from a reaction vial and swab the closure with either an alcohol swab or a suitable bacteriostatic agent.
2. Place the reaction vial in a suitable lead vial shield (minimum wall thickness 1/8 inch) which has a fitted lead cap. Obtain 2 to 10 mL of sterile, non-pyrogenic sodium pertechnetate Tc 99m, using a shielded syringe.
3. The recommended maximum amount of Technetium Tc 99m to be added to a reaction vial is 37.0 gigabecquerels (1000 mCi). Sufficient sodium pertechnetate is to be used for the reconstitution of a reaction vial to ensure that the dose of medronate administered does not exceed 10 mg. Sodium pertechnetate Tc 99m solutions containing an oxidizing agent are not suitable for use.
4. Using a shielded syringe, add the sodium pertechnetate Tc 99m solution to the reaction vial aseptically.
5. Place the lead cap on the reaction vial shield and agitate the shielded reaction vial until the contents are completely dissolved. The solution must be clear and free of particulate matter before proceeding.
6. Assay the product in a suitable calibrator, record the radioassay information on the label with a radiation warning symbol, and apply it to the reaction vial.
7. Withdrawals for administration must be made aseptically using a shielded sterile syringe and needle. Since the reaction vials contain nitrogen to prevent oxidation of the complex, they should not be vented. If repeated withdrawals are made, minimize the replacement of contents with room air.