Give a one-step route to the following molecule using a Michael reaction. Give suitable conditions and...
Propose a suitable synthetic route to perform the following transformations. List the reagents and conditions at each step and the structures of the precursors.
H2C N H3C- ОН НЫС CH3
Example #2 Synthesis the molecule on the right from the one the left. Give reagents, conditions and intermediate molecules in each step. ?????? Br
1. Consider the following molecule (12 marks total) i. Provide the reaction conditions, and major product, for the monobromination of this molecule (2 marks) ii. Provide the full arrow pushing mechanism for the formation of the major product (making sure to include all initiation, and propagation steps as well as one termination step) (4 marks) (Continuation of Question 1) iii. Provide an explanation for why only one product is obtained through monobromination of this molecule (2 marks) iv. When reacting...
Provide conditions for the following reactions. More than one step may be needed. Incorporate conditions that would give you the optimum yield, and be mindful of 1. stereochemical details. (4 pts each) a b. но ОН For each reaction below, please draw the starting material or the major (singular) product, including any pertinent stereochemical details. (3 pts each) 2. a. 3. Hg(OAc)2, D20 2. KOt-Bu 1.TsCl Он 4. NaBH t-BuOH EtgN etherol b. 3. СHBES 2. LDA 1. HBr KOt-Bu,...
5. Provide the complete reaction conditions (reagents, solvents) required transformations. More than one step may be required for each reaction arrow, be numbered 1), 2) etc. (12 marks) ents, solvents) required to complete the following uired for each reaction arrow, in which case the steps must DO
Propose the most efficient synthetic route to make the following
compound starting from the indicated reagents and any other
reagents, clearly identifying the reaction conditions at each step
and the structure of the intermediates formed.
Propose the most efficient synthetic route to make the following compound starting from the indicated reagents and any other reagents, clearly identifying the reaction conditions at each step and the structure of the intermediates formed. *Note: This will require more than 3 steps* ohin 3...
Question 1 Ph н он (a) Give a detailed one step retrosynthetic analysis of Compound A based on Grignard chemistry and in the process identify two possible routes for its synthesis (2 marks) (b) Give all reagents and conditions for a synthesis of A based on one of your answers to part (a) (2 marks) (c) Would you expect A to form as a single stereoisomer? Explain your answer (2 marks) (Total for question 1 = 6 marks)
Question 1...
4-Suggest a synthesis of the target molecule from the indicated starting material. More than one step will be required. For each step of your reaction sequence, show reagents used and product(s) formed. No curved arrows are required.(6 Marks)
1) Choose one molecule from the set and create an 8-step synthesis scheme using the chosen molecule as your starting material. You need to write the complete set of reagents and draw the product expected from each step. Reagents typically used together are considered one step, e.g. 1) LAH 2) H.O should be considered as one step. Your 8 steps must include at least one reaction from each of the chapters, aldehydes and ketones, carboxylic acid derivatives, alcohols. You can...
1) Choose one molecule from the set and create an 8-step synthesis scheme using the chosen molecule as your starting material. You need to write the complete set of reagents and draw the product expected from each step. Reagents typically used together are considered one step, e.g. 1) LAH 2) H2O should be considered as one step. Your 8 steps must include at least one reaction from each of the chapters, aldehydes and ketones, carboxylic acid derivatives, alcohols. You can...