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DUI YUM SEM LUIS 2. (5 Pt) Explain dynamic reciprocity, and how it can be used in tissue engineering U s design. t th coll co
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Dynamic reciprocity is basically the ongoing, bidirectional interaction that takes place between cells and the microenvironment, around them specifically the extracellular matrix (ECM)(Thorne, ‎2015). In multicellular organisms, signals of the micro-environment are interpreted by the cells interpret. These signals lead to the coordination of the growth and development of the different tissues and organs and. According to Bissell et al. the functioning of tissue is regulated dynamically and reciprocally. The micro-environment, formed by the extracellular matrix (ECM) sends signals to the cells which reach the nucleus and control the cellular behavior according to the theory called ‘dynamic reciprocity’. These concepts are important for tissue engineering, a multidisciplinary science applying the principles of engineering and life sciences for the development of biological substitutes for restoring, maintaining and improving the functions of tissues. Thus the concept that cellular behavior is directed by the modification of the cell micro-environments leads to the usage of the biomaterials for building and imitating the ECM. The biomaterials or scaffolds should have precise characteristics as each cell resides in a different micro-environment,(Urrutia, 2017)

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