Question

Question 4 A new drug is being tested in the clinical trial. The first group of patients receives the drug by two modes of administration, by mouth and intravenously. After receiving the drug (oral or i.v.), blood is drawn every hour to determine the concentration of drug in the bloodstream. After the trial is over, the pharmacologists and physicians determine that the drug can be given by mouth. Which answer best describes how this conclusion was determined? Not yet answered Points out of 1.0 Flag question Select one: a. The half-life was calculated and it was high for both methods. b. The therapeutic window was very narrow c. The area under the curve for oral administration was sufficiently high d. The drug undergoes first order kinetics during elimination. e. The drug has a high first-pass effect and is metabolized well in the liver

Answer 1

The correct option is e,  

Ie,the drug has a high first pass effect and is metabolized well in the liver

In oral administration the drug will metabolize well in liver and the first pass effect is high so it help in metabolism and helps in fast introduction into circulation without bypassing