Question

Compound #201912 is an environmental contaminant that was recently discovered in the drinking water of a local town. Compound #201912 originates from a local paper mill, and the data suggest that the compound causes acute kidney toxicity at low plasma concentrations. Interestingly, the compound readily builds up in adipose, not the plasma. Therefore, the local government warrants that the activities of the paper mill do not need to be regulated. However, your knowledge of drug distribution leads you to believe that this accumulation might be a bigger issue. Explain why in two sentences max

Answer 1

Fluoride compound was the environmental contaminant that was recently discovered in the drinking water of a local town.

Exposure to high concentration of fluoride can cause kidney damage, ultimately cause chronic kidney disease.Kidney help to prevent the build up of toxic fluoride level in the body that can be excreted through urine.When kidney exposure to high concentration of fluoride.

Fluoride metabolism:

About 90% absorbed through in the gastrointestinal tract that was transported to the blood stream and is distributed to the organs.The peak concentration is 20-60min after consumption.In the plasma the fluoride may bind to the plasma protein. The excessive consumption of fluoride can cause adverse effects and produce immediate effects in the tubular area in the kidney,inhibiting of tubular reabsorption,changes in urinary ion excretion by the kidney disruption of collagen biosynthesis in the body can damage kidney by affecting the functioning of kidney enzymes.

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