Question

The healthcare provider ordered methotrexate 40 mg PO twice a week as a maintenance dose for an adult who has leukemia. If the recommended maintenance dose is 20-30 mg/m? PO twice a week, is the prescribed order safe for the patient whose BSA is 2.12 m?? O A. No, it is an overdose. OB. No, it is an underdose. OC. Yes, it is safe OD. insufficient information to answer the question

Answer 1

Ordered methotrexate= 40 mg PO twice a week (PO means orally)

Recommended dose= 20-30 mg/m² twice a weak

The recommended dose as per the BSA of patient = 20 mg X 2.12 to 30 X 2.12 mg

An effective safe recommended dosing in this patient   = 42.4 mg to 63.6 mg twice a week

Since the ordered methotrexate dose i.e. 40  mg PO twice a week and it is within the individualized safe dose range of patient (42.4 mg to 63.6 mg twice a week), Hence is safe.

Means option C is correct.

Answer 2

The safe range is 42.4-63.6 so it would be an underdose. Answer is B