Question

is this answer correct for question 4 ?

QUESTION 4 A 12-year-old girl has developed hyperemia, itching and tearing on both eyes, and sneezing and rhinorrhea. She has had these episodes in the past couple of summers since the family moved to the Midwest. Direct skin tests are performed for any reaction to common grass pollens, cat fur and dust mites. A wheal-and-flare reaction occurs quickly after 10 minutes. Pathogenesis of her condition involves which of the following? Immune Complexes O NK response OTH2 cells and IgE Antibodies O d. IgM and IgG antibodies directed against mucosal epithelium ARRIAK

Answer 1

The correct answer is C. TH2 cells and IgE Antibodies

Her symptoms are the characteristics of Type 1 hypersensitivity reaction. Type 1 hypersensitivity are mediated by IgE antibodies, mast cells, basophils and cytokine products of TH2 cells. Type 1 hypersensitivity is mainly characterised by wheel-and-flare reaction.

Immune complexes are components of Type lll hypersensitivity reaction. Complexes of antigen and antibody form in the circulation and then deposited in the susceptible tissues. The clinical manifestation relates to the tissue deposition such as vasculitic (skin), serum sickness ( systemic), nephritis and extrinsic allergic alveolitis.

Natural Killer cells rapidly respond to virally infected cells and tumour formation in the absence of antibodies. NK cells are part of the innate immune system.

IgM and IgG antibodies supports an auto immune mechanism of injury. Type ll or antibody mediated hypersensitivity is mediated by IgM or IgG targetting membrane associated antigens.