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D.K., a 72-year-old man, had a myocardial infarction (MI) 5 years ago. He has been diagnosed...

D.K., a 72-year-old man, had a myocardial infarction (MI) 5 years ago. He has been diagnosed with classic (stable) angina. D.K. is prescribed acebutolol. His baseline vital signs are blood pressure 108/58; pulse 56 (at times irregular); and respirations 28. His past medication history includes asthma.

D.K. comes to the clinic with complaints of “dizzy spell and wheezing” His blood pressure is 86/50, pulse 46, and respirations 30. His acebutolol was stopped, and diltiazem, was ordered.

  1. In what ways could diltiazem benefit D.K and what other drug regimen might be helpful to D.K.? What are the advantages and disadvantages of calcium channel blockers
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Answer #1

benefits of diltiazem

increases blood supply and thus oxygen to the heart.it relaxes blood vessels, so the heart has no need to work hard.

Mr.D.K.has a history of myocardial infarction, so, consuming diltiazem reduces the risk of chest pain.

other drug regimens

antianginal drugs - eg: nitroglycerine(direct and non-specific smooth muscle relaxation)

salicylates-eg: Aspirin (platelet inhibitors)

anticoagulants-eg: heparin

fibrinolytic agents- eg: streptokinase

anti-hyperlipidemic -eg: rosuvastatin

advantages of calcium channel blockers

can be given to patients with obstructive pulmonary disease, safely.

can be used to those patients who are contraindicated with beta blockers.

high clearance rate. (> 90 % metabolised through the liver and excreted in urine)

disadvantages

after long term use of diltiazem, there is more chance to rebound worsening of angina.

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