Question

If this patient has IGG2 subclass deficiency based on the diagrams below. what other diseases mimic the IGG2 subclass deficiency and what test result did you use to eliminate them from the consideration.

Test Patient Result Normal Result WBC 6,600/ul 4000-7,000/u Differential 67% Neutrophils 25% Lymphocytes 6% Monocytes 2% Eosinophils 86% T lymphocyte 10% B lymphocyte 4% NK cells 40-60% 20-40% 2-8% 1-4% 80-90% 10-12% 3-5% 2.0 Lymphocytes T lymphocyte CD4/CD8 9.0 Ratio DTH Skin test for tuberculin and C albicans Normal response 1500 mg/d 65 mg/dl 52 mg/dl 600-1400 mg/dl 60-380 40-345 lgG Serum Levels IgA Serum levels gM Serum levels mRNA levels for MHC Normal Levels mRNA levels for B2MG Normal Levels

Answer 1

Some of the diseases that may mimic the IGG2 subclass deficiency include :

1. Agammaglobulinemia

2. B-Cell and T-Cell Combined Disorders

3. Chromosomal Breakage Syndromes

4. Pediatric Bruton Agammaglobulinemia

5. Rubella

6. Transient Hypogammaglobulinemia of Infancy

The laboratory studies help to differentiate these diseases with IGG2 deficiency include

1. Determining specific antibody levels to antigens helps to differentiate antigen-specific antibody deficiency (ASAD) from specific antibody deficiency (SAD).

2. IgG subclass deficiency can be measured through ELISA, radial immunodiffusion