Question

antiarrhythmic drugs questions

0 points Class I sodium channel blockers are divided into subclasses (IA, IB, IC) based on their: * Level of binding to plasma proteins, as indicated by the percent unbound in plasma Rate of sodium channel binding & dissociation, as indicated by the recovery time constant Conformation of sodium channels during which they bind, indicated as Open, Resting, or Inactive O Duration of activity in the body, as indicated by their plasma half-life Which subclass selectively blocks sodium channels more O points at fast heart rates than at normal heart rates: * O Class IA (example Procainamide) O Class IB (example Lidocaine) O Class IC (example Propafenone)

Answer 1

Class I sodium channel blockers are anti arrhythmic agents tht block to and bind the fast sodium channels that are responsible for rapid depolarization.these are divided into Ia,Ib,Ic depending upon rate of sodium channel binding and dissociation as indicated by the recovery time constant.

Class IB,they have fast onset and offset kinetic potential.they have more effects at faster heart rate.these agents will decrese vmax in particular cells and increase action potential.