Question 3 (M3 - Biopolymers Chemistry and Synthesis, continued overleaf) The synthesis of building block 5...
Question 3 (M3 - Biopolymers Chemistry and Synthesis, continued overleaf) The synthesis of building block 5 used for assembly of a collagen peptide is shown below: (a) OH dioxane, MeOH HCI H-Hyp-OMeN 4N NaOH Boc ВОР. ElgN ОН MeO HCI H-Gly-OMe, EDC HOBt, DIPEA, DMF он Boc Boc но 4 OMe a) 1 M HCI, 3 days, RT b) Fmoc-OSu, EtsN Fmoc он Fmoc-Pro-Hyp-Gly-OH (Fmoc-POG-OH) HN он Synthesis of Fmoc-Pro-Hyp-Gly-OH (Fmoc-POG-OH). No protecting group was necessary for the hydroxyl group in hydroxy proline (Hyp). Suggest a possible explanation. Which protecting group would have been chosen for the hydroxy group when using a protected hydroxy proline derivative? How is it ultimately removed? (i)