Question

Researchers are interested in testing the effectiveness of a new immunosuppressive therapy to be used post-transplant to reduce graft failure in the host. Suppose researchers investigating this new therapy are concerned about the dangerous side-effects of the drug. For instance, participants that would like to enroll in the study are not allowed to already have diabetes, as the immunosuppressive agent has been found to drastically increase fasting glucose levels, which could be very dangerous for diabetics. This means, however, that participants that enter and are treated with the new drug may develop diabetes as time goes on. Suppose the following table addresses the incidence of diabetes in the study depending on treatment group. 68 IType II Diabetes No Type II Diabetes Total Investigational Drug 41 27 Best standard of Care 12 Total 153 90 63 75 143 What is the incidence of diabetes in the group after the follow-up period? 33.01% o 30.06% 25.02% 37.06%

Answer 1

Polution = 29 foscidence rates No. of individuals having dabetes Total person time at risk during period = 53 143 = 0.3706 = 37.064.