Question

SOS 4 & 5

bo V/pid. 2137185-at-content-na-15926494-2/courses/CHEM400,01-FA2018/CHEM400%20F18%2 4. When the glucocorticoid receptor binds to its receptor in the el... a. what is the effect of this binding on the expression of the Annexin I gene? b. what is the effect of this binding on the expression of the CoX-2 gene? c. what is the net effect on inflammation? 5. In step 7 of glycolysis, 1,3-BPG (1,3-bisphosphoglycerate) is converted into 3-PG (3- phosphoglycerate), and ATP is synthesized. The AG for this reaction is -18.9 k]/mol Use the cellular concentrations and the provided information to answer the questions that follow. Be careful with units and rounding. Cellular concentrations: ATP: 1.85 mM 1,3-BPG: 0.001 mM ADP: 0.14 mM 3-PG: 0.12 mM a. What is the AG for this reaction? (Use the temperature of the human body, 37 °c (310 K)). b. Is this reaction in the cell far from equilibrium? (circle one) yes/no c. Is this reaction likely to be a control point or bypass point? (circle one) yes/na

Answer 1

4. Glucocorticoids are the anti-inflammatory compounds which effects on theinflammation process.These effects are carried by the Glucocorticoid receptor (GR's) binding to the glucocorticoids (GC).This binding mediated by the nuclear receptor brings about some changes at the gene level expression that leads to some of the major inflammatory pathways.