Question

H,N. Py H,N. H,N ,C Cl P1 H,N H,N NH H2 NH, H, Compounds A-D are anti-cancer drugs in curren! cⅢical use or under investigation in trials. () Assign oxidation states to all of the platinum ions in molecules A-D (3 marks) () Describe the similar mechanism of action for compounds A-C accounting for any differences. Rationalise the data below in terms of providing effective cancer treatment. Cytotoxicity (CCso in vitro) Maximum tolerated dose 2.3 uM 200 mg m2 51.6 nM 20 mg m2

Answer 1

Oxidation State (O.S)charge on ligands charge on complex 0.5 charge on complex-charge on ligand All ammine ligands are neutral and hence has O charge Cl is negative ligand with -1 charge OAc is a negative ligand with -1 charge And hence the oxidation state of Pt in A is - 0 - (2x(-1)) - +2 Oxidation state of Pt in B 0 -(2x(-1)) - +i2 Oxidation state of Pt in C 0-(4x(-1): +4 Oxidation state of Pt in D:4 - 0 +4 4 H,N Compounds A-D are anti-cancer drugs in curre cical use or under investigation in trials. Assign oxidation states to all of the platinum ions in molecules A-D (3 marks)