Would you expect the Friedel-Crafs reaction of a benzene with (S)-2-chlorobutane to yield an optically active or racemic product. Explain your answer.
Would you expect the Friedel-Crafs reaction of a benzene with (S)-2-chlorobutane to yield an optically active...
3. Benzene reacts with optically pure (R)-2-chlorobutane and AlCl3. Is the product R? S? Racemic? Explain mechanistically.
3.2 An optically active carboxylic acid, (s) 2-phemypropanoic acid, is brominated treatment with 1) PBrs. Bra; 2) Hzo) under Hell-Wolhard-Zelinski conditions. Wili me product which s formed in the reaction be optically active or racemic? Explain yaur prediction in detain 3.3 The following synthetic route does not produce the desired product. Explain what is wrong with the reaction CO2Et CH3CHCO2Et 2) PhBr 3) Hyde heat
Consider the two reactions below for the optically active alkyl halide, (R)-2-chloropentane. The first reaction occurs rapidly at room temperature and gives an optically active product. The second reaction, starting with the same alkyl halide, occurs slowly at room temperature and gives a non-optically active product (racemic mixture). Draw a mechanism (include all H's and lone pairs) for cach reaction and explain how the mechanism leads to the observed results. Hics CHES- CH.OH CH,OH
FULL SCREEN PRINTER VERSION 4 BACK NE Integrated Problem 18.76 Benzene was treated with (R)-2-chlorobutane in the presence of aluminum trichloride, and the resulting product mixture was found to be optically inactive. 18.41 18.42 em Get help answering Molecular Drawing questions. Draw the expected organic product(s) of the reaction assuming that conditions are chosen to favor monoalkylation. Using wedges and dashes, indicate the stereochemistry, 18.53 18.54 ? Edit SHOW HINT Choose the correct explanation, why the product mixture is optically...
how do you predict the major deuterium containing product(s). abd
whether it is optically active or racemic.
to label it as upiicuny 1.) NaH он I Ozc DC 2.) Br D₃C KO+Bu bulky bax, less subs. racemic KOET D₃C racemic NaN3 Br
Which of the following solutions would you expect to be optically active? Circle all that apply 5 g of (2R,3S)-2-bromo-3-chloropentane 5 g of (2R,3R)-2-bromo-3-chloropentane dissolved in an unknown volume of organic 10 g (R)-carvone and 10 g (S) carvone dissolved in 500 mL of CH2C12 10 g 2-chloro-2-bromopropane dissolved in 100 mL H20 solvent Solution formed by adding 5.0 mL of 1-methylbutane to 10 mL of CH3OH Solution formed by mixing 8.0 mL of 2.0 M (+)-2-butanol and 4.0 mL...
Benzene underwent a Friedel-Crafts acylation reaction followed
by a Clemmensen reduction. The product gave the 1H NMR
spectrum shown above. What acyl chloride was used in the
Friedel-Crafts acylation reaction? Hint: It would be helpful
if you first assign a structure to the compound shown in the
1H NMR spectrum.
Benzene underwent a Friedel-Crafts acylation reaction followed by a Clemmensen reduction. The product gave the 1H NMR spectrum shown above. What acyl chloride was used in the Friedel-Crafts acylation reaction?...
The alkane formed by hydrogenation of (S)-4-methyl-1-hexyne is optically active, but the one formed by hydrogenation of (S)-3-methyl-1-pentyne is not. Explain. Would you expect the products of hydrogenation of these two compounds in the presence of Lindlar palladium to be optically active?
4. The first reaction is a Friedel-Craft acylation (or C-acylation) of benzene. The second and third reactions involve phenol. Explain why the second reaction (C-acylation) is a very poor reaction, even in the presence of AlCl3, and why the third reaction (0-acylation) is preferred. H3C0 + HCI Friedel-Craft acylation (or C-acylation) 8. Mode - 13 + HCI HCCI Extremely poor yield. Decent yield (0-acylation)
Question 5: Draw the product(s) of this reaction (stereochemistry is important of products are optically active or not. + HBO