Organocuprates predominantly react to give 1,4-addition products with a,ß-unsaturated carbonyl species, while Grignard reagents often add...
Organocuprates predominantly react to give 1,4-addition products with a.ß-unsaturated carbonyl species, while Grignard reagents often add to the carbonyl, in a process referred to as 1,2-addition. To increase the yield of 1,4-addition products, Cul is added to convert an easily prepared Grignard reagent into an organocuprate reagent in situ. Sa MgBr Cul, THF, -30°C For this reaction draw the structure of the 1,2-addition product prepared without Cul, including stereochemistry, assuming that the major product is derived from the more stable...