3. a. Use the Henderson-Hasselbach equation to determine the ratio of HCO3- to H2CO3 in the...
3. a. Use the Henderson-Hasselbach equation to determine the ratio of HCO3- to H2CO3 in the patient’s blood 10 hours after aspirin ingestion.
b. How does this compare to the ratio of HCO3- to H2CO3 in normal blood (indicate value used from the range given in the table). (pKa1=6.35). c. Can the H2CO3/HCO3- system serve as an effective buffer in this patient? Explain
Homework Answers
Q3
assume pH of stomach = 1.5
then
pH = pKa + log(HCO3-/H2CO3)
1.5 = 6.35 + log(HCO3-/H2CO3)
HCO3-/H2CO3 = 10^(1.5-6.35) = 0.000014125
ratio = 0.000014125
b)
compare vs. ratio in blood
assume pH blood = 7.4 approx
pH = pKa + log(HCO3-/H2CO3 )
7.40 = 6.35 + log(HCO3-/H2CO3 )
HCO3-/H2CO3 = 10^(7.40 - 6.35 ) = 11.220
ratio = 11.220
there is much more HCO3- in ionic state in blood than in stomach
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