Question

What is the best route for converting the alcohol to the ether as shown below using a substitution reaction or a sequence of substitution reactions while preserving the steroochemistry at the chiral center? OH OCH a. NaOCHy b.i. PC13; ii. NaOCH ci.HCI; N.CH OH 4. CH3OH Oei. HCI; il NOCH f. LICH3

Answer 1

Answers:

1. c

2. e

3. f

Refer the pic given below for all the answers and their detailed explanation:
CASSMATE tute Page 1 DI OCH > () 4u & (ii) CH₃OH best regent OH बा + HU SN' reaction Retension Product ce ARCH + CH3OH t HU let's check ether options NOOCH3 will read with alcold to forni salt OH Na OLM3 ona' t. Choh by pula ") Neochy son t SN2 ot + Petz given SN? reaction. so inversion of Product forms but we have to get retension Product d) CH, OH will und react generally generally with the with the alcomel (1) HU to NaOCHy 1 OH +HU INI F habet be - SP strony base gives Elimination reaction

Cl₂ + AcOH 12 2? OSCH ello Mono-Halogention of d-Carbon occurs with U₂ orchlorination i If we take Cl2 in Basic medium , then poly subtitution of Chlorine ond-c-alan wil take place 94 we chose bare haoh then flaloform reaction will 1 ove get chloroform as seperate product ОССМ * chz +NGUY + CH3 thtetufosse So, take acid ACOH flt thy (2 Acom By -OH Best regent > Help Noh, ho 17 BH3. (ii) H2O2 iNOM, H₂O Hybonation oxidation reaction Antimarlovnikov produelt gf we take 4got then Markeovnikov, product will in Ago (7)
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