Question

PRINTER VERSION BACK NEXT Integrated Problem 22.91 x Incorrect. Nicotine is well known for its addictive characteristic in cigarettes. Interestingly, it has also been suggested to have potential therapeutic potential in central nervous system disorders such as Alzheimer's disease, Parkinson's disease, and depression. However, due to the toxic side effects of nicotine, derivatives are being developed, such as compound 2, which shows much lower toxicity and exhibits analgesic (pain-inhibiting) properties (Bioorg. Med. Chem. Lett. 2006, 16, 2013-2016). Provide an efficient synthesis of compound 2 from compound 1. If a step is not needed, write NA in that step: 2 но с 1 2 Choose from the list of reagents NH, NH HyO", NaHCN b. 4 2*, Nam C HjOh, NaHCN 5 H H H.C CH d. Hyo. NajN 9. NaCrO, H 50 H30 1. NaBH, MOH HO". NaBCN H сн. H30, NaHCN h. s ro, H30", acetone 1) LAH 2) 20 1. PCC, CH, INN Step 1 Step 2

Answer 1

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- ce Ne ce XS LiAlHy , H2O "K" Ho HO. 0 "}] PCC NH₂ ce is Hoot ii) NUBH₃ CN H b" 0 cal I T E> so, step. I ik Step: 2 step: 3 CS Scanned with CamScanner
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