Question

please slove it on paper

Question 4. (20 pts.) The objectives of a study by Skjelbo et al. were to examine (a) the relationship between Chloroguanide metabolism and efficacy in malaria prophylaxis and (b) the mephenytoin metabolism and its relationship to chloroguanide metabolism among Tanzanians. From information provided by urine specimens from the 216 subjects, the investigators computed the ratio of unchanged S-mephenytoin to R-mephenytoin (S/R ratio). The results were as follows: 0.0269 0.0400 0.0550 0.0550 0.0650 0.0670 0.0700 0.0720 0.0760 0.0850 0.0870 0.0870 0.0880 0.0900 0.0900 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.0990 0.1000 0.1020 0.1040 0.1050 0.1050 0.1080 0.1080 0.1090 0.1090 0.1090 0.1160 0.1190 0.1200 0.1230 0.1240 0.1340 0.1340 0.1370 0.1390 0.1460 0.1480 0.1490 0.1490 0.1500 0.1500 0.1500 0.1540 0.1550 0.1570 0.1600 0.1650 0.1650 0.1670 0.1670 0.1677 0.1690 0.1710 0.1720 0.1740 0.1780 0.1780 0.1790 0.1790 0.1810 0.1880 0.1890 0.1890 0.1920 0.1950 0.1970 0.2010 0.2070 0.2100 0.2100 0.2140 0.2150 0.2160 0.2260 0.2290 0.2390 0.2400 0.2420 0.2430 0.2450 0.2450 0.2460 0.2460 0.2470 0.2540 0.2570 0.2600 0.2620 0.2650 0.2650 0.2680 0.2710 0.2800 0.2800 0.2870 0.2880 0.2940 0.2970 0.2980 0.2990 0.3000 0.3070 0.3100 0.3110 0.3140 0.3190 0.3210 0.3400 0.3440 0.3480 0.3490 0.3520 0.3530 0.3570 0.3630 0.3630 0.3660 0.3830 0.3900 0.3960 0.3990 0.4080 0.4080 0.4090 0.4090 0.4100 0.4160 0.4210 0.4260 0.4290 0.4290 0.4300 0.4360 0.4370 0.4390 0.4410 0.4410 0.4430 0.4540 0.4680 0.4810 0.4870 0.4910 0.4980 0.5030 0.5060 0.5220 0.5340 0.5340 0.5460 0.5480 0.5480 0.5490 0.5550 0.5920 0.5930 0.6010 0.6240 0.6280 0.6380 0.6600 0.6720 0.6820 Mth251 Page 2 (a) From these data construct the following distributions: frequency, relative frequency, cumulative frequency, and cumulative relative frequency; and the following graphs: histogram, frequency polygon. (b) The investigators defined as poor metabolizers of mephenytoin any subject with an S/R mephenytoin ratio greater than 9. How many and what percentage of the subjects were poor metabolizers? (c) How many and what percentage of the subjects had ratios less than 7? Between .3 and .6999 inclusive?

dear freind they gave me only these questions to slove i dont know anything else

forget that and answer these

Answer 1

Class Interval = 0.09
Class Interval	Frequency	Cumulative Frequency	Relative	Cumulative Relative
0-0.089	13	13	0.068	0.068
0.09-0.179	75	88	0.391	0.459
0.18-0.269	32	120	0.167	0.626
0.27-0.359	23	143	0.120	0.746
0.36-0.449	24	167	0.125	0.871
0.45-0.539	11	178	0.057	0.928
0.54-0.629	10	188	0.052	0.98
0.63-0.719	4	192	0.021	1.001

Midpoint	Frequency
0.04495	13
0.13495	75
0.22495	32
0.31495	23
0.40495	24
0.49495	11
0.58495	10
0.67495	4

B) No Value are greater than 0.9

C) 63 Subjects had S/R values less than 0.70 = 63/192 = 0.3281

Hence it is in the range of 0.3-0.699

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