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14. HIV-1 Protease is an enzyme made by HIV that hydrolyzes the long viral polyprotein into...
Question 3: The HIV protease is manufactured by the virus to cleave the polyprotein into functional parts of the virion. The velocity of the HIV protease with a viral protein target without inhibitor (column 1) and with a low concentration of a target inhibitory drug (column 2), shown below. The inhibitor was made by chemically modifying the viral protein target. Sphingosine (UM) V. (mg 'min) with no inhibitor ([U] = 0) 5.00E-06 1.00E-05 2.00E-05 4.00E-05 8.00E-05 1.60E-04 4.00E-05 5.33E-05 6.40E-05...
Please help me with these two problems. I will rate the answers. 1. The HIV-1 protease, an important enzyme in the life cycle of the human immunodeficiency virus-1 (HIV-1), is a good drug target for the treatment of HIV and AIDS. A protein produced by the virus, p6*, is an HIV-1 protease inhibitor. The activity of the HIV-1 protease was measured in the presence and absence of p6* using an assay involving an artificial substrate, as shown below. NH Lys...
b) (10 points) Acetylcholinesterase is a hydrolase that hydrolyzes the neurotransmitter acetylcholine. Caffeine inhibits the action of Acetylcholinesterase and clinical studies have indicated that it can be involved in the slowing of Alzheimer disease pathology. P11149 is a galanthamine analogue that has also been studied as a potential drug for treating Alzheimer disease. The initial reaction rate for acetylcholine hydrolysis was measured at an enzyme concentration of 5×10-8 M with no inhibitor present, and in the presence of caffeine or...
31. A common side effect is HIV medications is lipodistrophy, which is... A. gastric distress when eating fatty foods C. numbness in the fingers and toes B. redistribution of body fat D. Anemia 32. What happened each time the AIDS definition was changed? A. Diagnosing AIDS became significantly more difficult. B. There was a decrease in the number of AIDS cases reported. C. Diagnosing AIDS became available only in exclusive testing centers. D. There was an increase in the number...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
Based on the document below, 1. Describe the hypothesis Chaudhuri et al ids attempting to evaluate; in other words, what is the goal of this paper? Why is he writing it? 2. Does the data presented in the paper support the hypothesis stated in the introduction? Explain. 3.According to Chaudhuri, what is the potential role of thew alkaline phosphatase in the cleanup of industrial waste. CHAUDHURI et al: KINETIC BEHAVIOUR OF CALF INTESTINAL ALP WITH PNPP 8.5, 9, 9.5, 10,...