The mixed Claisen condensation of two esters is given and the major product needs to be given. The Claisen condensation takes place in the presence of a base such as sodium ethoxide and results in the formation of ketoester.
The Claisen condensation is a reaction between two esters having hydrogen in presence of a base. The final product is a ketoester.
The base abstracts hydrogen from one of the ester to form a carbanion. The carbanion then attacks the other ester molecule and forms an intermediate. Finally, an ethoxide ion is eliminated from the ester molecule to give ketoester.
The carbanion formed is as follows:
The carbanion attacks on the carbonyl carbon of ethyl isobutyrate.
The final product formed is as follows:
Ans:The major product of the given reaction is as follows:
The second ester forms preferentially the enolate (the first step of the condensation
reaction). The ether part will be eliminated from the other ester.
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