How do I get from the first
compound to the second one? It should only take about 2-3
steps.
Homework Answers
The compound 2 can be prepared from compound 1 by Grignard reaction followed by oxidation as shown below
The mechanism is as follows.
Excessive Grignard addition of Ethyl Magnesium bromide will attack all the lactone carbonyl two times to form two tertiary alcohols. Also, one secondary as well as one primary alcohol will be formed in the molecule. Under oxidation conditions, primary alcohol will be converted into carboxylic acid group and secondary alcohols will be converted into ketone. Tertiary alcohols will be unaffected under the oxidation conditions.
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