Question

SN2 stepwise mechanism with arrows, the substrate and solvent effect on the reaction, and the stereochemical and regiochemical outcome for the reaction

Answer 1

The SN2 reaction involves displacement of a leaving group (usually a halide or a tosylate), by a nucleophile. This reaction works the best with methyl and primary halides because bulky alkyl groups block the backside attack of the nucleophile

SN² General mechanism - -x -> Nu-(- + xo Nu = Nucleophile , x=dearing group Example "OH + BRO

steneochemistry Because of the backside nucleophile , invension of occurs. attack of the contigunation н c C H - BIL 1 - HO-C AH Hool H H Substrate effect: ~ This reaction works best with methyl and primeny hallides because bulky alkys groups block the backside attack of the nucleophile. Reactivity of hallide Solvent effect. → Protic solvents such as H₂O & alcohols stabilizes the nucleophile so that it won't reach mucho. - Therefore a good plan oprotic solvent is required for SN? reaction eg. (ethers, DCM etc.)